💊 PCAT Exam Prep

Nucleophilic acyl substitution occurs at:

A Alkyl carbons
B Carbonyl carbons of carboxylic acid derivatives (esters, amides, acid chlorides, anhydrides)
C Aromatic rings
D Triple bonds only

✓ Correct Answer: Option B

Acyl substitution: nucleophile attacks electrophilic carbonyl C → tetrahedral intermediate → leaving group departs. Not SN2.

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