A client is admitted to the emergency department with suspected opioid overdose. Which medication should the nurse anticipate administering first to reverse respiratory depression?

✓ Correct Answer: Option B

Naloxone is an opioid antagonist used to rapidly reverse the effects of opioid overdose, particularly respiratory depression. Flumazenil reverses benzodiazepine effects. Protamine sulfate reverses heparin. Activated charcoal is for oral ingestions.