🏥 USMLE Exam Prep

Which of the following is the primary cell type responsible for synthesizing and secreting collagen and other components of the extracellular matrix in most connective tissues?

A Macrophage
B Adipocyte
C Fibroblast
D Mast cell

✓ Correct Answer: Option C

Fibroblasts are the most common cells in connective tissue proper. Their main function is to synthesize and secrete the protein fibers (like collagen and elastin) and ground substance that constitute the extracellular matrix.

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