Which of the following genes typically acts as a tumor suppressor, requiring inactivation of both alleles for its oncogenic effect?

A MYC

B RAS

C BRCA1

D HER2

✓ Correct Answer: Option C

BRCA1 is a classic tumor suppressor gene, following Knudson's 'two-hit' hypothesis, where both copies must be inactivated for increased cancer risk. MYC, RAS, and HER2 are oncogenes, typically requiring only one mutated allele.

💡 Why is C) the correct answer?

The correct answer to the question "Which of the following genes typically acts as a tumor suppressor, requiring inactivation of both alleles for its oncogenic effect?" is Option C: BRCA1.

The other options — A) MYC, B) RAS, D) HER2 — are incorrect for this USMLE Exam Prep question. As explained above: BRCA1 is a classic tumor suppressor gene, following Knudson's 'two-hit' hypothesis, where both copies must be inactivated for increased cancer risk. MYC, RAS, and HER2 are oncogenes, typically requir…

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This 3-level USMLE Exam Prep question from the Step 1 – Basic Sciences topic is part of BrainForge Quiz's free exam preparation library. Each question includes the correct answer and a detailed explanation to help you understand the underlying concept, not just memorize the answer.

How to use this page: Read the question above, consider all four options (A through D), then check the highlighted correct answer and explanation. For active timed practice, start a free USMLE Exam Prep practice test or use flashcards for spaced repetition review.

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Which of the following genes typically acts as a tumor suppressor, requiring inactivation of both alleles for its oncogenic effect?

✓ Correct Answer: Option C

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