🏥 USMLE Exam Prep

Which of the following enzymes is a key regulatory point for gluconeogenesis, bypassed by fructose-2,6-bisphosphate?

A Phosphofructokinase-1
B Fructose-1,6-bisphosphatase
C Pyruvate kinase
D Glucose-6-phosphatase

✓ Correct Answer: Option B

Fructose-1,6-bisphosphatase is a key regulatory enzyme in gluconeogenesis, catalyzing the dephosphorylation of fructose-1,6-bisphosphate. It is inhibited by fructose-2,6-bisphosphate, which promotes glycolysis and thus opposes gluconeogenesis.

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