🏥 USMLE Exam Prep

Which enzyme is allosterically activated by fructose-2,6-bisphosphate, thereby promoting glycolysis in the liver?

A Hexokinase
B Phosphofructokinase-1 (PFK-1)
C Pyruvate kinase
D Fructose-1,6-bisphosphatase

✓ Correct Answer: Option B

Fructose-2,6-bisphosphate is a potent allosteric activator of phosphofructokinase-1 (PFK-1), the committed step in glycolysis. It also inhibits fructose-1,6-bisphosphatase, suppressing gluconeogenesis.

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