🏥 USMLE Exam Prep

Which bacterial toxin acts by cleaving SNARE proteins, thereby inhibiting acetylcholine release at the neuromuscular junction, leading to flaccid paralysis?

A Shiga toxin
B Tetanospasmin
C Diphtheria toxin
D Botulinum toxin

✓ Correct Answer: Option D

Botulinum toxin (from Clostridium botulinum) inhibits acetylcholine release at the neuromuscular junction by cleaving SNARE proteins, causing flaccid paralysis. Tetanospasmin also cleaves SNAREs but inhibits inhibitory neurotransmitters, causing spastic paralysis.

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