The p53 tumor suppressor gene is known as the guardian of the genome because it:

Question

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B) Arrests the cell cycle or induces apoptosis in cells with DNA damage. p53: activated by DNA damage → upregulates p21 (CDK inhibitor) → G1 arrest. If damage irreparable, triggers apoptosis. Mutated in >50% of human cancers.

The p53 tumor suppressor gene is known as the guardian of the genome because it:

✓ Correct Answer: Option B

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