The majority of DNA viruses replicate their genome in the nucleus of the host cell. Which of the following DNA viruses is a notable exception to this rule, replicating primarily in the cytoplasm?

✓ Correct Answer: Option C

Poxviruses are unique among DNA viruses because they replicate their entire life cycle, including DNA replication, within the cytoplasm of the host cell. Most other DNA viruses, like herpes simplex, adenovirus, and papillomavirus, replicate in the nucleus.