🏥 USMLE Exam Prep

The citric acid cycle (Krebs cycle) takes place in:

A The cytoplasm
B The mitochondrial matrix
C The endoplasmic reticulum
D The nucleus

✓ Correct Answer: Option B

The citric acid cycle occurs in the mitochondrial matrix. Pyruvate enters mitochondria, is converted to acetyl-CoA, which enters the cycle producing NADH, FADH2, GTP, and CO2.

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