🏥 USMLE Exam Prep

Stimulation of the adrenal medulla by the sympathetic nervous system primarily leads to the release of which neurotransmitters/hormones into the bloodstream?

A Acetylcholine and norepinephrine
B Norepinephrine and epinephrine
C Epinephrine and dopamine
D Serotonin and substance P

✓ Correct Answer: Option B

The adrenal medulla acts as a modified sympathetic ganglion. Upon sympathetic preganglionic stimulation (acetylcholine), it releases primarily epinephrine (about 80%) and norepinephrine (about 20%) directly into the circulation.

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