Sickle cell disease is caused by a mutation in:
✓ Correct Answer: Option B
SCD: point mutation in beta-globin gene (Glu→Val at position 6, codon 6). HbS polymerizes when deoxygenated → sickle-shaped RBCs → vaso-occlusive crises, hemolytic anemia.
SCD: point mutation in beta-globin gene (Glu→Val at position 6, codon 6). HbS polymerizes when deoxygenated → sickle-shaped RBCs → vaso-occlusive crises, hemolytic anemia.