In a double-blind randomized controlled trial:

A Only the patient is blinded

B Neither the patients nor the investigators know who receives the treatment or placebo

C Only the researcher is blinded

D No one is involved

✓ Correct Answer: Option B

Double-blind RCT: participants AND researchers unaware of allocation. Minimizes placebo effect and observer bias. Gold standard for clinical trials. Single-blind: only participant unaware.

💡 Why is B) the correct answer?

The correct answer to the question "In a double-blind randomized controlled trial:" is Option B: Neither the patients nor the investigators know who receives the treatment or placebo.

The other options — A) Only the patient is blinded, C) Only the researcher is blinded, D) No one is involved — are incorrect for this USMLE Exam Prep question. As explained above: Double-blind RCT: participants AND researchers unaware of allocation. Minimizes placebo effect and observer bias. Gold standard for clinical trials. Single-blind: only participant unaware.

📚 About This USMLE Exam Prep Practice Question

This 2-level USMLE Exam Prep question from the Step 3 - Clinical Practice topic is part of BrainForge Quiz's free exam preparation library. Each question includes the correct answer and a detailed explanation to help you understand the underlying concept, not just memorize the answer.

How to use this page: Read the question above, consider all four options (A through D), then check the highlighted correct answer and explanation. For active timed practice, start a free USMLE Exam Prep practice test or use flashcards for spaced repetition review.

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In a double-blind randomized controlled trial:

✓ Correct Answer: Option B

📚 About This USMLE Exam Prep Practice Question

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