🏥 USMLE Exam Prep

Glass III antiarrhythmic drugs like amiodarone primarily work by:

A Blocking sodium channels
B Blocking potassium channels to prolong the action potential duration and refractory period
C Blocking calcium channels
D Blocking beta receptors

✓ Correct Answer: Option B

Class III antiarrhythmics: K+ channel blockers → prolonged AP duration and ERP → prolonged QT. Amiodarone has properties of all 4 classes. Used for atrial and ventricular arrhythmias.

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