For naive T-cell activation to occur, in addition to the T-cell receptor binding to MHC-peptide complex, a crucial co-stimulatory signal is required. Which receptor-ligand interaction provides this signal?

Question

BrainForge Quiz · Accepted Answer

C) CD28-B7. The binding of CD28 on the T-cell to B7 (CD80/CD86) on the antigen-presenting cell provides the essential co-stimulatory signal (Signal 2) necessary for full activation of naive T-cells and preventing anergy.

For naive T-cell activation to occur, in addition to the T-cell receptor binding to MHC-peptide complex, a crucial co-stimulatory signal is required. Which receptor-ligand interaction provides this signal?

✓ Correct Answer: Option C

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