Degeneration of dopaminergic neurons in the substantia nigra pars compacta is a hallmark of Parkinson's disease. This primarily affects which neurotransmitter pathway?

✓ Correct Answer: Option C

The nigrostriatal pathway connects the substantia nigra pars compacta to the striatum (caudate and putamen) and is crucial for motor control. Its degeneration leads to the characteristic motor symptoms of Parkinson's disease.