🏥 USMLE Exam Prep

A virus uses its own RNA-dependent RNA polymerase to synthesize mRNA directly from a negative-sense RNA genome. This replication strategy is characteristic of which type of virus?

A dsDNA virus
B Positive-sense ssRNA virus
C Negative-sense ssRNA virus
D Retrovirus

✓ Correct Answer: Option C

Negative-sense ssRNA viruses cannot be directly translated. They must carry their own RNA-dependent RNA polymerase to synthesize a positive-sense mRNA strand from their negative-sense genome, which can then be translated into proteins.

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