🏥 USMLE Exam Prep

A renal biopsy from a patient with long-standing rheumatoid arthritis reveals amorphous, eosinophilic deposits in the glomeruli that stain positive with Congo red and show apple-green birefringence under polarized light. What is the most likely diagnosis?

A Diabetic nephropathy
B Amyloidosis
C Minimal change disease
D Focal segmental glomerulosclerosis

✓ Correct Answer: Option B

The description of amorphous, eosinophilic deposits that stain positive with Congo red and exhibit apple-green birefringence under polarized light is pathognomonic for amyloidosis. This condition often complicates chronic inflammatory diseases like rheumatoid arthritis.

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