🏥 USMLE Exam Prep

A patient with hypercholesterolemia is prescribed atorvastatin. What is the primary mechanism of action of this drug class?

A Increasing bile acid reabsorption
B Inhibiting HMG-CoA reductase
C Activating lipoprotein lipase
D Blocking cholesterol absorption

✓ Correct Answer: Option B

Statins, such as atorvastatin, primarily act by inhibiting HMG-CoA reductase. This enzyme is the rate-limiting step in cholesterol biosynthesis in the liver, leading to decreased intracellular cholesterol and increased LDL receptor expression.

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