🏥 USMLE Exam Prep

A patient with chronic kidney disease experiences metabolic acidosis. Which of the following best explains the kidney's primary role in correcting this imbalance?

A Increased reabsorption of bicarbonate in the proximal tubule.
B Enhanced secretion of hydrogen ions by Type A intercalated cells.
C Decreased production of ammonia by proximal tubule cells.
D Reduced excretion of titratable acids via glomerular filtration.

✓ Correct Answer: Option B

In metabolic acidosis, the kidneys compensate by enhancing the secretion of hydrogen ions, primarily by Type A intercalated cells in the collecting duct, and increasing bicarbonate reabsorption. Ammonia production also increases, aiding acid excretion.

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