A patient with adrenal insufficiency is given a high dose of exogenous cortisol. Which of the following changes would be observed in the patient's pituitary gland?

✓ Correct Answer: Option C

Exogenous cortisol exerts negative feedback on the hypothalamus and pituitary gland. This inhibits the release of corticotropin-releasing hormone (CRH) from the hypothalamus and adrenocorticotropic hormone (ACTH) from the anterior pituitary.