🏥 USMLE Exam Prep

A patient presents with severe muscle spasms, lockjaw (trismus), and opisthotonus after sustaining a puncture wound. The symptoms are due to a bacterial toxin that prevents the release of inhibitory neurotransmitters. Which neurotransmitter release is directly inhibited by this toxin?

A Acetylcholine
B Norepinephrine
C GABA and Glycine
D Dopamine

✓ Correct Answer: Option C

Tetanus toxin, produced by Clostridium tetani, acts by cleaving SNARE proteins, preventing the release of inhibitory neurotransmitters GABA and glycine from Renshaw cells in the spinal cord, leading to uncontrolled muscle spasms.

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