🏥 USMLE Exam Prep

A patient presents with acute onset of severe watery diarrhea, described as 'rice-water stools,' without fever or significant abdominal pain. The causative bacterium produces a toxin that permanently activates adenylate cyclase. Which organism is most likely responsible?

A Staphylococcus aureus
B Clostridium difficile
C Vibrio cholerae
D Salmonella enteritidis

✓ Correct Answer: Option C

Vibrio cholerae produces cholera toxin, which irreversibly activates adenylate cyclase via ADP-ribosylation of the Gs protein, leading to excessive fluid secretion into the gut lumen and 'rice-water stools'.

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