🏥 USMLE Exam Prep

A patient is prescribed ciprofloxacin for a bacterial infection. The mechanism of action of ciprofloxacin involves the inhibition of which bacterial enzymes?

A Peptidoglycan transpeptidases
B 50S ribosomal subunit
C DNA gyrase and topoisomerase IV
D Dihydrofolate reductase

✓ Correct Answer: Option C

Ciprofloxacin is a fluoroquinolone antibiotic that targets bacterial DNA replication. It specifically inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, preventing DNA unwinding, replication, and repair, leading to bacterial cell death.

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