A patient is diagnosed with Xeroderma Pigmentosum. Which DNA repair mechanism is most likely deficient in this patient?

A Base excision repair

B Nucleotide excision repair

C Mismatch repair

D Non-homologous end joining

✓ Correct Answer: Option B

Xeroderma Pigmentosum is an autosomal recessive disorder caused by a defect in nucleotide excision repair (NER), which is responsible for removing bulky DNA adducts like pyrimidine dimers formed by UV radiation.

💡 Why is B) the correct answer?

The correct answer to the question "A patient is diagnosed with Xeroderma Pigmentosum. Which DNA repair mechanism is most likely deficient in this patient?" is Option B: Nucleotide excision repair.

The other options — A) Base excision repair, C) Mismatch repair, D) Non-homologous end joining — are incorrect for this USMLE Exam Prep question. As explained above: Xeroderma Pigmentosum is an autosomal recessive disorder caused by a defect in nucleotide excision repair (NER), which is responsible for removing bulky DNA adducts like pyrimidine dimers formed by U…

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This 2-level USMLE Exam Prep question from the Step 1 – Basic Sciences topic is part of BrainForge Quiz's free exam preparation library. Each question includes the correct answer and a detailed explanation to help you understand the underlying concept, not just memorize the answer.

How to use this page: Read the question above, consider all four options (A through D), then check the highlighted correct answer and explanation. For active timed practice, start a free USMLE Exam Prep practice test or use flashcards for spaced repetition review.

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A patient is diagnosed with Xeroderma Pigmentosum. Which DNA repair mechanism is most likely deficient in this patient?

✓ Correct Answer: Option B

📚 About This USMLE Exam Prep Practice Question

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