🏥 USMLE Exam Prep

A patient experiencing significant blood loss develops hypotension. Which of the following compensatory mechanisms is primarily responsible for increasing total peripheral resistance to maintain blood pressure?

A Decreased sympathetic outflow to resistance vessels.
B Release of atrial natriuretic peptide (ANP).
C Activation of the renin-angiotensin-aldosterone system.
D Increased parasympathetic tone to the heart.

✓ Correct Answer: Option C

Hypotension due to blood loss activates the renin-angiotensin-aldosterone system (RAAS). Angiotensin II, a potent vasoconstrictor produced by the RAAS, directly increases total peripheral resistance to help maintain blood pressure.

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