🏥 USMLE Exam Prep

A patient experiences acute shortness of breath, wheezing, and urticaria immediately after being stung by a bee. This reaction is primarily mediated by the degranulation of mast cells and basophils. Which type of hypersensitivity reaction is this?

A Type I (Immediate)
B Type II (Cytotoxic)
C Type III (Immune Complex)
D Type IV (Delayed)

✓ Correct Answer: Option A

Type I hypersensitivity reactions are IgE-mediated, leading to the rapid degranulation of mast cells and basophils upon re-exposure to an allergen. This causes the release of histamine and other mediators, resulting in immediate symptoms like anaphylaxis, urticaria, and wheezing.

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