A patient develops severe muscle rigidity, hyperthermia, and rhabdomyolysis after receiving general anesthesia with succinylcholine and halothane. This condition is known as malignant hyperthermia and is primarily due to a defect in which receptor?

✓ Correct Answer: Option B

Malignant hyperthermia is an autosomal dominant disorder caused by mutations in the ryanodine receptor (RyR1), a calcium release channel on the sarcoplasmic reticulum. This leads to uncontrolled calcium release in skeletal muscle, causing sustained contraction and heat generation.