A patient develops a rash and blistering 48-72 hours after exposure to poison ivy. This delayed-type hypersensitivity reaction is primarily mediated by which of the following immune cells?

✓ Correct Answer: Option C

Delayed-type hypersensitivity (Type IV) reactions, such as contact dermatitis from poison ivy, are primarily cell-mediated, involving T lymphocytes (specifically CD4+ helper T cells and CD8+ cytotoxic T cells) and macrophages, not antibodies or neutrophils.