🏥 USMLE Exam Prep

A newborn is diagnosed with DiGeorge syndrome, characterized by absent thymus and parathyroid glands, and cardiac defects. This condition results from an abnormality in the development of which embryonic structures?

A Neural crest cells
B First pharyngeal arch
C Third and fourth pharyngeal pouches
D Notochord

✓ Correct Answer: Option C

DiGeorge syndrome (often due to 22q11 deletion) involves defective development of the third and fourth pharyngeal pouches. These structures normally give rise to the thymus (leading to T-cell deficiency) and the parathyroid glands (leading to hypocalcemia).

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