A histological examination of ischemic tissue reveals irreversible cell injury characterized by nuclear shrinkage, condensation, and increased basophilia. This morphological change is known as:

✓ Correct Answer: Option C

Pyknosis is the irreversible condensation of chromatin in the nucleus of a dying cell, leading to nuclear shrinkage and increased basophilia. It is an early sign of irreversible cell injury, preceding karyorrhexis and karyolysis.