A genetic disorder is observed only in offspring of affected mothers, with all sons and daughters of an affected mother having the disease, but no offspring of an affected father being affected. This pattern of inheritance is most consistent with which of the following?

The correct answer to the question "A genetic disorder is observed only in offspring of affected mothers, with all sons and daughters of an affected mother having the disease, but no offspring of an affected father being affected. This pattern of inheritance is most consistent with which of the following?" is Option D: Mitochondrial.

The other options — A) Autosomal dominant, B) X-linked recessive, C) Autosomal recessive — are incorrect for this USMLE Exam Prep question. As explained above: Mitochondrial inheritance involves genes located in mitochondrial DNA, which is inherited exclusively from the mother, because sperm contribute almost no mitochondria to the zygote. Therefore, only a…