🏥 USMLE Exam Prep

A genetic disorder is characterized by progressive neurological deterioration, chorea, and psychiatric symptoms, often with an earlier age of onset and increased severity in successive generations. This phenomenon is known as anticipation and is typically associated with which type of genetic mutation?

A Point mutation
B Frameshift mutation
C Trinucleotide repeat expansion
D Chromosomal translocation

✓ Correct Answer: Option C

Anticipation, where symptoms worsen and appear earlier in subsequent generations, is characteristic of disorders caused by trinucleotide repeat expansions, such as Huntington's disease, myotonic dystrophy, and fragile X syndrome.

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