🏥 USMLE Exam Prep

A child with a history of severe sunburns and multiple skin cancers presents with extreme photosensitivity. This condition is most likely due to a defect in which DNA repair mechanism?

A Mismatch repair
B Base excision repair
C Nucleotide excision repair
D Non-homologous end joining

✓ Correct Answer: Option C

Xeroderma Pigmentosum is caused by a defect in nucleotide excision repair (NER), which is responsible for removing pyrimidine dimers formed by UV radiation, leading to increased risk of skin cancer.

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