🏥 USMLE Exam Prep

A biopsy of an ischemic organ shows cells with preserved architecture but denatured proteins and enzymatic degradation. The nucleus is undergoing pyknosis, karyorrhexis, and karyolysis. Which type of necrosis is most likely occurring?

A Liquefactive necrosis
B Caseous necrosis
C Coagulative necrosis
D Fat necrosis

✓ Correct Answer: Option C

Coagulative necrosis is characterized by cell death in which the architecture of the tissue is preserved for a short period, with cellular proteins denaturing. This is typically seen in ischemic injury to solid organs, excluding the brain.

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