A biopsy of a lung mass reveals poorly differentiated cells with neuroendocrine features, described as 'small, round blue cells' with scant cytoplasm and high mitotic activity. Immunohistochemistry is positive for chromogranin and synaptophysin. Which type of lung cancer does this most accurately describe?
✓ Correct Answer: Option D
Small cell carcinoma is characterized by 'small, round blue cells' and neuroendocrine differentiation, often staining positive for chromogranin and synaptophysin. It is strongly associated with smoking and has an aggressive course.