🏥 USMLE Exam Prep

A bacterium acquires a plasmid that encodes for an enzyme capable of hydrolyzing the beta-lactam ring of penicillin. This mechanism of resistance is an example of which of the following?

A Efflux pumps
B Target site modification
C Enzymatic degradation
D Reduced permeability

✓ Correct Answer: Option C

The hydrolysis of the beta-lactam ring by enzymes like beta-lactamase (penicillinase) directly inactivates the antibiotic. This is a common mechanism of resistance to penicillin and cephalosporins via enzymatic degradation.

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