🏥 USMLE Exam Prep

A 72-year-old male with a history of severe COPD presents with increased dyspnea, cough, and sputum production for 3 days. He is hypoxic with an SpO2 of 88% on room air. After initiating supplemental oxygen and bronchodilators, which additional intervention has been shown to reduce mortality in patients with acute COPD exacerbations?

A Prophylactic antibiotics for all exacerbations
B Non-invasive positive pressure ventilation (NIPPV)
C High-dose inhaled corticosteroids
D Theophylline

✓ Correct Answer: Option B

Non-invasive positive pressure ventilation (NIPPV) significantly improves outcomes, including reduced mortality and intubation rates, in patients with acute COPD exacerbations and respiratory acidosis or severe dyspnea.

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