A 68-year-old woman with metastatic lung cancer reports severe dyspnea at rest, despite supplemental oxygen. Her pain is well-controlled. What is the most appropriate pharmacologic intervention to address her dyspnea?

✓ Correct Answer: Option B

Low-dose opioids are the first-line pharmacologic treatment for refractory dyspnea in palliative care, even without pain, as they reduce the perception of breathlessness by acting on central respiratory centers.