🏥 USMLE Exam Prep

A 68-year-old patient with severe COPD presents with acute worsening of dyspnea, increased cough, and purulent sputum. Oxygen saturation is 88% on room air. Arterial blood gas shows pH 7.28, pCO2 65 mmHg, pO2 55 mmHg. What is the most appropriate initial ventilation strategy?

A Intubation and mechanical ventilation
B Non-invasive positive pressure ventilation (NIPPV)
C High-flow nasal cannula
D Venturi mask with 40% oxygen

✓ Correct Answer: Option B

NIPPV is the preferred initial ventilation strategy for patients with acute exacerbations of COPD and hypercapnic respiratory failure, as it can reduce the need for intubation and improve outcomes. It supports ventilation without the risks of intubation.

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