🏥 USMLE Exam Prep

A 68-year-old male presents with urinary urgency, frequency, nocturia, and a weak urinary stream. Digital rectal examination reveals a smooth, symmetrically enlarged prostate without nodules. His PSA is 3.5 ng/mL. What is the most appropriate initial pharmacotherapy for his symptoms?

A Finasteride
B Tamsulosin
C Sildenafil
D Metronidazole

✓ Correct Answer: Option B

The patient's symptoms are consistent with benign prostatic hyperplasia (BPH). Alpha-1 adrenergic blockers like tamsulosin are first-line therapy, rapidly relaxing prostatic smooth muscle and improving urinary flow. Finasteride reduces prostate size but has a slower onset of action.

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