🏥 USMLE Exam Prep

A 68-year-old female presents to the emergency department with acute onset right-sided weakness and aphasia. Symptoms started 2 hours ago. CT scan of the head is negative for hemorrhage. Which of the following findings would be an absolute contraindication to administering intravenous alteplase?

A Blood pressure 170/95 mmHg
B History of transient ischemic attack (TIA) 6 months ago
C Platelet count of 75,000/µL
D Blood glucose level of 280 mg/dL

✓ Correct Answer: Option C

A platelet count less than 100,000/µL is an absolute contraindication for intravenous alteplase due to the increased risk of hemorrhagic transformation. Elevated blood pressure can be managed, and TIA history is not a contraindication.

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