A 65-year-old man presents with progressive fatigue, unintentional weight loss, and night sweats for several months. Physical examination reveals painless cervical, axillary, and inguinal lymphadenopathy, and splenomegaly. Laboratory studies show normocytic anemia, thrombocytopenia, and lymphocytosis with smudge cells. Which of the following is the most likely diagnosis?
✓ Correct Answer: Option B
The constellation of progressive fatigue, weight loss, night sweats (B symptoms), generalized lymphadenopathy, splenomegaly, and particularly lymphocytosis with smudge cells on peripheral smear is highly characteristic of Chronic Lymphocytic Leukemia (CLL).