🏥 USMLE Exam Prep

A 65-year-old male presents to the ED with substernal chest pain radiating to his left arm, unrelieved by nitroglycerin. ECG shows ST-segment depressions in leads V4-V6. Initial management should include immediate administration of which of the following, assuming no contraindications?

A Aspirin, clopidogrel, heparin, and labetalol
B Aspirin, nitroglycerin, morphine, and oxygen
C Aspirin, P2Y12 inhibitor (e.g., clopidogrel), heparin, and beta-blocker
D Thrombolytic therapy, aspirin, and clopidogrel

✓ Correct Answer: Option C

Initial management of NSTEMI/unstable angina includes antiplatelet therapy (aspirin and a P2Y12 inhibitor), anticoagulation (heparin), and beta-blockers, along with symptom relief. Thrombolytics are generally for STEMI.

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