A 65-year-old male is discharged after an acute ischemic stroke. His workup reveals no evidence of cardioembolic source or large vessel stenosis, suggesting a lacunar stroke. He has a history of hypertension and hyperlipidemia. What is the most appropriate long-term antiplatelet therapy for secondary stroke prevention?

The correct answer to the question "A 65-year-old male is discharged after an acute ischemic stroke. His workup reveals no evidence of cardioembolic source or large vessel stenosis, suggesting a lacunar stroke. He has a history of hypertension and hyperlipidemia. What is the most appropriate long-term antiplatelet therapy for secondary stroke prevention?" is Option B: Aspirin 81 mg daily.

The other options — A) Warfarin, C) Rivaroxaban, D) Prasugrel — are incorrect for this USMLE Exam Prep question. As explained above: For patients with non-cardioembolic ischemic stroke, antiplatelet therapy is crucial for secondary prevention. Aspirin 81 mg daily is a standard first-line agent, unless contraindicated. Oral anticoa…