🏥 USMLE Exam Prep

A 62-year-old female undergoes elective total hip arthroplasty. She has no prior history of DVT/PE. Which of the following is the MOST appropriate prophylactic measure against venous thromboembolism in the immediate postoperative period?

A Aspirin 81 mg daily
B Mechanical compression devices only
C Low molecular weight heparin (LMWH) or fondaparinux
D Warfarin with an INR target of 2.0-3.0

✓ Correct Answer: Option C

For major orthopedic surgeries like total hip arthroplasty, guidelines recommend pharmacologic prophylaxis (e.g., LMWH, fondaparinux, or direct oral anticoagulants) for an extended period, often in combination with mechanical methods, due to high DVT/PE risk.

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