A 60-year-old male with septic shock remains hypotensive (MAP <65 mmHg) despite receiving 3 liters of intravenous fluids. His lactate is 4.5 mmol/L. What is the most appropriate first-line vasopressor to initiate?

✓ Correct Answer: Option C

Norepinephrine is recommended as the first-line vasopressor in septic shock because it effectively increases mean arterial pressure through alpha-1 adrenergic effects with less significant chronotropic effects compared to other options.