A 6-month-old infant presents with developmental regression, hypotonia, and a "cherry-red spot" on macular examination. Deficiency of which enzyme is most consistent with this presentation?

✓ Correct Answer: Option C

This clinical picture describes Tay-Sachs disease, an autosomal recessive lysosomal storage disorder caused by a deficiency of Hexosaminidase A, leading to the accumulation of GM2 ganglioside in neurons.