🏥 USMLE Exam Prep

A 58-year-old patient with metastatic pancreatic cancer reports severe, constant abdominal pain despite taking oral morphine 30 mg every 4 hours. He is drowsy but rousable. What is the most appropriate next step in managing his pain?

A Increase the dose of oral morphine to 60 mg every 4 hours
B Add a non-steroidal anti-inflammatory drug (NSAID)
C Switch to a transdermal fentanyl patch
D Administer a rapid-acting opioid rescue dose and reassess the baseline regimen

✓ Correct Answer: Option D

When a patient on a scheduled opioid regimen experiences breakthrough pain, the initial step is to administer a rapid-acting rescue dose, then reassess the patient's pain and the adequacy of their baseline scheduled regimen.

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