A 58-year-old man with type 2 diabetes mellitus and a history of cardiovascular disease has an HbA1c of 8.2% despite being on metformin and glipizide. His BMI is 31 kg/m². His eGFR is 70 mL/min/1.73m². Which of the following medications would be MOST appropriate to add to his regimen to improve glycemic control and reduce cardiovascular risk?

The correct answer to the question "A 58-year-old man with type 2 diabetes mellitus and a history of cardiovascular disease has an HbA1c of 8.2% despite being on metformin and glipizide. His BMI is 31 kg/m². His eGFR is 70 mL/min/1.73m². Which of the following medications would be MOST appropriate to add to his regimen to improve glycemic control and reduce cardiovascular risk?" is Option C: Liraglutide.

The other options — A) Pioglitazone, B) Sitagliptin, D) Insulin glargine — are incorrect for this USMLE Exam Prep question. As explained above: Liraglutide, a GLP-1 receptor agonist, has demonstrated cardiovascular benefit in patients with type 2 diabetes and established cardiovascular disease, in addition to improving glycemic control and p…